The origin of the cholesterol hypothesis
Experts who have challenged the acclaimed importance or benefits of LDL cholesterol say that we’ve made a lot of wrong measurements.
According to the researchers, cholesterol may not be a direct marker of heart disease. They also say that total cholesterol may not be an accurate metric.
According to the researchers, focusing on triglycerides might be the best way to monitor heart health.
In the 1960s, there was serious controversy over the primary cause of heart disease. One group focused on sugar as the culprit, while the other group insisted that dietary fat, especially saturated fat, was the primary cause.
John Yudkin championed the accusation against sugar, while Ancel Keys suggested that dietary fat was to blame. Yudkin was a British physiologist while Keys was an American scientist.
The battle continued until the 1970s, but then, three major discoveries relegated fat as the primary enemy of heart health.
The first discovery centered around familial hypercholesterolemia, a genetic condition characterized by a lack of LDL receptor in the liver, usually leading to teenage death from a heart attack.
The second discovery was that LDL cholesterol level was raised by dietary fat.
And the third argument was that there was a correlation between high LDL levels and heart disease.